Control of Fibrosis in Systemic Scleroderma
نویسندگان
چکیده
منابع مشابه
Fibrocytes in Scleroderma Lung Fibrosis
Systemic sclerosis (SSc) or “Scleroderma” is a disease characterized by cutaneous and visceral fibrosis that affects both the skin and internal organs. The worldwide prevalence ranges from 50-300 cases per million (Chifflot et al., 2008) and much of the morbidity in this population results from pulmonary complications. In fact, nearly 70% of scleroderma patients show some form of lung disease. ...
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The association of retroperitoneal fibrosis and systemic sclerosis is reported from a patient positive for the HLA-B27 antigen. This appears to be the first report of such an association. Pathological features common to the 2 syndromes are discussed and the literature is reviewed.
متن کاملSystemic Sclerosis (Scleroderma)
labmedicine.com November 2005 Volume 36 Number 11 LABMEDICINE 723 Systemic sclerosis is a chronic disease of unknown etiology characterized by abnormal accumulation of fibrous tissue in the skin and multiple organs.1 Scleroderma derives its name from the Greek words “sclerosis” (hardness) and “derma” (skin), thus aptly named “hard skin,” a feature that is common to all the different types of sc...
متن کاملSystemic Sclerosis (Scleroderma)
Systemic sclerosis (SSc) is a multisystem autoimmune disease in which there is increased fibroblast activity resulting in abnormal growth of connective tissue. This causes vascular damage and fibrosis. Fibrosis occurs in skin, the gastrointestinal (GI) tract, heart, lungs and other internal organs. Vascular manifestations include secondary Raynaud's phenomenon, ischaemia of extremities, pulmona...
متن کاملSystemic Sclerosis / Scleroderma (SScl)
While it is called by many names and comes in different varieties, SScl is characterized by one basic problem: overproduction of collagen. Collagen is an important protein in the body that is a component of scar tissue, which allows injuries to heal. When too much collagen is deposited, however, a number of problems can arise, and this is the basic obstacle that must be faced in patients with S...
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ژورنال
عنوان ژورنال: Journal of Investigative Dermatology
سال: 1993
ISSN: 0022-202X
DOI: 10.1038/jid.1993.30